The housing group has been chosen by Brent Council to deliver 208 new homes. It plans to make 122 of the properties available for social rent, while the remaining 86 homes will be for sale on the open market.
"We’re proud to be a part of the important regeneration of South Kilburn," said Rod Cahill, chief executive of Catalyst Housing. "Catalyst is committed to building strong sustainable communities. This isn’t just about high quality new homes, our commitment to the area will continue long after the last brick is laid."
The proposals for the estate have been designed by Lifschutz Davidson Sandilands Architects and include the demolition of four existing blocks of flats, which will be replaced by "low rise, modern apartments".
"The new homes have been designed to an exceptionally high quality and will create a fantastic place to live," said Andrew Donald, director of regeneration and major projects for Brent Council.
"Brent Council is determined to continue to drive forward the regeneration of South Kilburn and create a strong, vibrant, sustainable community where people choose to live now and in the future," Donald said.
Catalyst also plans to provide 15 construction-related training apprenticeships for local residents alongside the development.